Polygenic scores: Are they a public health hazard?

Polygenic hazard scores in preclinical Alzheimer disease.

Identifying asymptomatic older individuals at elevated risk for developing Alzheimer disease (AD) is of clinical importance. Among 1,081 asymptomatic older adults, a recently validated polygenic hazard score (PHS) significantly predicted time to AD dementia and steeper longitudinal cognitive decline, even after controlling for APOE ɛ4 carrier status. Older individuals in the highest PHS percent...

Predicting Alzheimer's disease: a polygenic hazard score.

the genetic factors that influence the development of alzheimer’s disease (ad) have been the subject of large international collaborative studies in recent years involving many thousands of patients and controls. genome wide association screens (gWas) have produced large datasets which include not only genetic linkage information but also clinical material such as age of disease onset and, in s...

Acyclovir as a public health hazard.

Public Health Progress and Race Progress--are They Incompatible?

Entered as second-class matter July 18, 1923, at the Post Offlce at Lancaster, Pa., under the Act of March 8, 1879. THE public health workers, the social workers, the civilizers, we are told, are corrupting the race; are destroying the race. By protecting us from our enemies, the bacteria and the viruses; by removing the sources of disease; by showing us how to avoid unfavorable conditions and,...

Test scores--are they a distorted proxy for achievement?

1097 New Questions in Strobel Case 1098 Researcher Accused of Plagiarism Resigns 1099 Ozone Plan: Tough Bargaining Ahead Animal Rightists Raid USDA Lab 1100 Test Scores-Are They a Distorted Proxy for Achievement? Briefing: Choppin Is New Head of Howard Hughes * Textbook Rulings Reversed 1101 Science and Mutual Self-Interest 1102 Toward an Academia Europaea? * EEC: Uniting to Meet High-Tech's Ch...